Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-type Signaling Molecules in <i>Streptomyces</i> <i>rochei</i>

Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-type Signaling Molecules in <i>Streptomyces</i> <i>rochei</i>

<i>Streptomyces rochei</i> 7434AN4 produces two structurally unrelated polyketide antibiotics lankacidin and lankamycin, and their biosynthesis is tightly controlled by butenolide-type signaling molecules SRB1 and SRB2. SRBs are synthesized by SRB synthase SrrX, and induce lankacidin and...

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Bibliographic Details
Main Authors: Aiko Teshima, Nozomi Hadae, Naoto Tsuda, Kenji Arakawa
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Biomolecules
Subjects:
<i>Streptomyces</i>
signaling molecule
biosynthesis
cytochrome P450
secondary metabolite
Online Access:https://www.mdpi.com/2218-273X/10/9/1237

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