Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)

Objectives To develop (part I) and validate (part II) an electronic fall risk clinical rule (CR) to identify nursing home residents (NH-residents) at risk for a fall incident.Design Observational, retrospective case–control study.Setting Nursing homes.Participants A total of 1668 (824 in part I, 844...

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Main Authors: Bjorn Winkens, Hugo M van der Kuy, Dennis Wong, Brigit P C van Oijen, Kim P G M Hurkens, Vanja Milosevic, Aimee Linkens, Carlota Mestres-Gonzalvo
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/5/e042941.full
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spelling doaj-55cd182822af40ceb7e2c510c3054d8b2021-09-28T07:00:05ZengBMJ Publishing GroupBMJ Open2044-60552021-06-0111510.1136/bmjopen-2020-042941Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)Bjorn Winkens0Hugo M van der Kuy1Dennis Wong2Brigit P C van Oijen3Kim P G M Hurkens4Vanja Milosevic5Aimee Linkens6Carlota Mestres-Gonzalvo7Methodology and Statistics, Maastricht University, Maastricht, The NetherlandsDepartment of Hospital Pharmacy, University Medical Center Rotterdam, Erasmus MC, Rotterdam, Zuid-Holland, The NetherlandsClinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Sittard-Geleen and Heerlen, Limburg, The NetherlandsClinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Sittard-Geleen and Heerlen, Limburg, The NetherlandsGeriatric Medicine, Department of Internal Medicine, Zuyderland Medisch Centrum, Heerlen, Limburg, The NetherlandsClinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Sittard-Geleen and Heerlen, Limburg, The NetherlandsInternal Medicine, Maastricht University Medical Centre+, Maastricht, Limburg, The NetherlandsClinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, Limburg, The NetherlandsObjectives To develop (part I) and validate (part II) an electronic fall risk clinical rule (CR) to identify nursing home residents (NH-residents) at risk for a fall incident.Design Observational, retrospective case–control study.Setting Nursing homes.Participants A total of 1668 (824 in part I, 844 in part II) NH-residents from the Netherlands were included. Data of participants from part I were excluded in part II.Primary and secondary outcome measures Development and validation of a fall risk CR in NH-residents. Logistic regression analysis was conducted to identify the fall risk-variables in part I. With these, three CRs were developed (ie, at the day of the fall incident and 3 days and 5 days prior to the fall incident). The overall prediction quality of the CRs were assessed using the area under the receiver operating characteristics (AUROC), and a cut-off value was determined for the predicted risk ensuring a sensitivity ≥0.85. Finally, one CR was chosen and validated in part II using a new retrospective data set.Results Eleven fall risk-variables were identified in part I. The AUROCs of the three CRs form part I were similar: the AUROC for models I, II and III were 0.714 (95% CI: 0.679 to 0.748), 0.715 (95% CI: 0.680 to 0.750) and 0.709 (95% CI: 0.674 to 0.744), respectively. Model III (ie, 5 days prior to the fall incident) was chosen for validation in part II. The validated AUROC of the CR, obtained in part II, was 0.603 (95% CI: 0.565 to 0.641) with a sensitivity of 83.41% (95% CI: 79.44% to 86.76%) and a specificity of 27.25% (95% CI 23.11% to 31.81%).Conclusion Medication data and resident characteristics alone are not sufficient enough to develop a successful CR with a high sensitivity and specificity to predict fall risk in NH-residents.Trial registration number Not available.https://bmjopen.bmj.com/content/11/5/e042941.full
collection DOAJ
language English
format Article
sources DOAJ
author Bjorn Winkens
Hugo M van der Kuy
Dennis Wong
Brigit P C van Oijen
Kim P G M Hurkens
Vanja Milosevic
Aimee Linkens
Carlota Mestres-Gonzalvo
spellingShingle Bjorn Winkens
Hugo M van der Kuy
Dennis Wong
Brigit P C van Oijen
Kim P G M Hurkens
Vanja Milosevic
Aimee Linkens
Carlota Mestres-Gonzalvo
Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
BMJ Open
author_facet Bjorn Winkens
Hugo M van der Kuy
Dennis Wong
Brigit P C van Oijen
Kim P G M Hurkens
Vanja Milosevic
Aimee Linkens
Carlota Mestres-Gonzalvo
author_sort Bjorn Winkens
title Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
title_short Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
title_full Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
title_fullStr Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
title_full_unstemmed Fall incidents in nursing home residents: development of a predictive clinical rule (FINDER)
title_sort fall incidents in nursing home residents: development of a predictive clinical rule (finder)
publisher BMJ Publishing Group
series BMJ Open
issn 2044-6055
publishDate 2021-06-01
description Objectives To develop (part I) and validate (part II) an electronic fall risk clinical rule (CR) to identify nursing home residents (NH-residents) at risk for a fall incident.Design Observational, retrospective case–control study.Setting Nursing homes.Participants A total of 1668 (824 in part I, 844 in part II) NH-residents from the Netherlands were included. Data of participants from part I were excluded in part II.Primary and secondary outcome measures Development and validation of a fall risk CR in NH-residents. Logistic regression analysis was conducted to identify the fall risk-variables in part I. With these, three CRs were developed (ie, at the day of the fall incident and 3 days and 5 days prior to the fall incident). The overall prediction quality of the CRs were assessed using the area under the receiver operating characteristics (AUROC), and a cut-off value was determined for the predicted risk ensuring a sensitivity ≥0.85. Finally, one CR was chosen and validated in part II using a new retrospective data set.Results Eleven fall risk-variables were identified in part I. The AUROCs of the three CRs form part I were similar: the AUROC for models I, II and III were 0.714 (95% CI: 0.679 to 0.748), 0.715 (95% CI: 0.680 to 0.750) and 0.709 (95% CI: 0.674 to 0.744), respectively. Model III (ie, 5 days prior to the fall incident) was chosen for validation in part II. The validated AUROC of the CR, obtained in part II, was 0.603 (95% CI: 0.565 to 0.641) with a sensitivity of 83.41% (95% CI: 79.44% to 86.76%) and a specificity of 27.25% (95% CI 23.11% to 31.81%).Conclusion Medication data and resident characteristics alone are not sufficient enough to develop a successful CR with a high sensitivity and specificity to predict fall risk in NH-residents.Trial registration number Not available.
url https://bmjopen.bmj.com/content/11/5/e042941.full
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