Structural mechanisms of phospholipid activation of the human TPC2 channel

Structural mechanisms of phospholipid activation of the human TPC2 channel

Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand-bound and apo states. The apo structure captures...

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Bibliographic Details
Main Authors: Ji She, Weizhong Zeng, Jiangtao Guo, Qingfeng Chen, Xiao-chen Bai, Youxing Jiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
two-pore channels
lysosome
cryo-EM
phosphoinositide
Online Access:https://elifesciences.org/articles/45222

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