Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits

Synthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein synthesis.

Bibliographic Details
Main Authors:	Luis E. Contreras-Llano, Conary Meyer, Yao Liu, Mridul Sarker, Sierin Lim, Marjorie L. Longo, Cheemeng Tan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16900-7

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spelling	doaj-55bac5fd16a4402198c0d94a339bb7812021-06-20T11:13:52ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16900-7Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuitsLuis E. Contreras-Llano0Conary Meyer1Yao Liu2Mridul Sarker3Sierin Lim4Marjorie L. Longo5Cheemeng Tan6Department of Biomedical Engineering, University of California, DavisDepartment of Biomedical Engineering, University of California, DavisDepartment of Biomedical Engineering, University of California, DavisSchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversityDepartment of Chemical Engineering, University of California, DavisDepartment of Biomedical Engineering, University of California, DavisSynthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein synthesis.https://doi.org/10.1038/s41467-020-16900-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Luis E. Contreras-Llano Conary Meyer Yao Liu Mridul Sarker Sierin Lim Marjorie L. Longo Cheemeng Tan
spellingShingle	Luis E. Contreras-Llano Conary Meyer Yao Liu Mridul Sarker Sierin Lim Marjorie L. Longo Cheemeng Tan Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits Nature Communications
author_facet	Luis E. Contreras-Llano Conary Meyer Yao Liu Mridul Sarker Sierin Lim Marjorie L. Longo Cheemeng Tan
author_sort	Luis E. Contreras-Llano
title	Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
title_short	Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
title_full	Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
title_fullStr	Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
title_full_unstemmed	Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
title_sort	holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Synthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein synthesis.
url	https://doi.org/10.1038/s41467-020-16900-7
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Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits

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