CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability

CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability

Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined. Methods:To identify the kinases that modulate...

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Bibliographic Details
Main Authors: Danmin Ou, Lin Chen, Jiang He, Zhuoxian Rong, Jie Gao, Zhi Li, Liyu Liu, Feiyu Tang, Jiang Li, Yuezhen Deng, Lunquan Sun
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-05-01
Series:Cancer Biology & Medicine
Subjects:
wnt/β-catenin signaling
cdk11
endosome
microtubule
sirt2
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1613

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