Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities

In vitroassays involving multiple cell types cannot control the stoichiometry or contact times of cell-cell interactions. Here, the authors present a patterned co-culture platform based on printed oligonucleotides capable of controlling cell-cell interactions of up to four different cell types at th...

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Main Authors:	Sisi Chen, Andrew W. Bremer, Olivia J. Scheideler, Yun Suk Na, Michael E. Todhunter, Sonny Hsiao, Prithvi R. Bomdica, Michel M. Maharbiz, Zev J. Gartner, David V. Schaffer
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10309

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spelling	doaj-55b29f78522547ffa0cce3eafe375b992021-05-11T11:11:48ZengNature Publishing GroupNature Communications2041-17232016-01-01711810.1038/ncomms10309Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communitiesSisi Chen0Andrew W. Bremer1Olivia J. Scheideler2Yun Suk Na3Michael E. Todhunter4Sonny Hsiao5Prithvi R. Bomdica6Michel M. Maharbiz7Zev J. Gartner8David V. Schaffer9California Institute for Quantitative Biosciences, University of California, BerkeleyDepartment of Bioengineering, University of California, BerkeleyDepartment of Bioengineering, University of California, BerkeleyDepartment of Bioengineering, University of California, BerkeleyDepartment of Pharmaceutical Chemistry, University of California, San FranciscoAdherenDepartment of Bioengineering, University of California, BerkeleyThe UC Berkeley—UCSF Graduate Program in Bioengineering, University of California, BerkeleyThe UC Berkeley—UCSF Graduate Program in Bioengineering, University of California, BerkeleyCalifornia Institute for Quantitative Biosciences, University of California, BerkeleyIn vitroassays involving multiple cell types cannot control the stoichiometry or contact times of cell-cell interactions. Here, the authors present a patterned co-culture platform based on printed oligonucleotides capable of controlling cell-cell interactions of up to four different cell types at the single-cell level.https://doi.org/10.1038/ncomms10309
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sisi Chen Andrew W. Bremer Olivia J. Scheideler Yun Suk Na Michael E. Todhunter Sonny Hsiao Prithvi R. Bomdica Michel M. Maharbiz Zev J. Gartner David V. Schaffer
spellingShingle	Sisi Chen Andrew W. Bremer Olivia J. Scheideler Yun Suk Na Michael E. Todhunter Sonny Hsiao Prithvi R. Bomdica Michel M. Maharbiz Zev J. Gartner David V. Schaffer Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities Nature Communications
author_facet	Sisi Chen Andrew W. Bremer Olivia J. Scheideler Yun Suk Na Michael E. Todhunter Sonny Hsiao Prithvi R. Bomdica Michel M. Maharbiz Zev J. Gartner David V. Schaffer
author_sort	Sisi Chen
title	Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
title_short	Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
title_full	Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
title_fullStr	Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
title_full_unstemmed	Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
title_sort	interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-01-01
description	In vitroassays involving multiple cell types cannot control the stoichiometry or contact times of cell-cell interactions. Here, the authors present a patterned co-culture platform based on printed oligonucleotides capable of controlling cell-cell interactions of up to four different cell types at the single-cell level.
url	https://doi.org/10.1038/ncomms10309
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Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities

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