Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis

Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis

Primary Myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by a skewed megakaryopoiesis and an overproduction of proinflammatory and profibrotic mediators that lead to the development of bone marrow (BM) fibrosis. Since we recently uncovered the upregula...

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Bibliographic Details
Main Authors: Elisa Bianchi, Samantha Ruberti, Sebastiano Rontauroli, Paola Guglielmelli, Simona Salati, Chiara Rossi, Roberta Zini, Enrico Tagliafico, Alessandro Maria Vannucchi, Rossella Manfredini
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
miR-34a-5p
nuclear receptor subfamily 4, group A, member 2 (NR4A2)
lymphoid enhancer-binding factor 1 (LEF1)
MYB
hematopoetic progenitor cells
hematopoietic differentiation
megakaryopoiesis
primary myelofibrosis
myeloproliferative neoplasms
macrophage
Online Access:http://www.mdpi.com/1422-0067/18/1/145

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