Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature

• Main Authors: Luize Otero, Daiane Correa de Souza, Rita de Cássia Tavares, Bernadete Evangelho Gomes, Telma França Padilha, Luiz Fernando Bouzas, Teresa de Souza Fernandez, Eliana Abdelhay
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética 2012-01-01
• Series: Genetics and Molecular Biology
• Subjects: monosomy 7; donor cell leukemia; bone marrow transplantation; severe aplastic anemia
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
• ISSN: 1415-4757; 1678-4685

Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.