Phage Display Approaches for the Isolation of Monoclonal Antibodies Against Dengue Virus Envelope Domain III from Human and Mouse Derived Libraries

Phage Display Approaches for the Isolation of Monoclonal Antibodies Against Dengue Virus Envelope Domain III from Human and Mouse Derived Libraries

Domain III of the dengue virus envelope protein (EDIII, aa295-395) has an immunoglobulin fold and is the proposed receptor-binding domain of the virus. Previous studies have shown that monoclonal antibodies against EDIII can be neutralizing and have therapeutic potential. Here, cloned Fab-phage libr...

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Bibliographic Details
Main Authors: Subhash G. Vasudevan, Brendon J. Hanson, Ravikumar Rajamanonmani, Moon Y. F. Tay, Patricia Susanto, Elfin Lim, Nicole J. Moreland
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:International Journal of Molecular Sciences
Subjects:
dengue
E protein
domain III
phage display
Fab
hybridoma
Online Access:http://www.mdpi.com/1422-0067/13/3/2618/

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