A comprehensive in silico analysis, distribution and frequency of human Nkx2-5 mutations; A critical gene in congenital heart disease

A comprehensive in silico analysis, distribution and frequency of human Nkx2-5 mutations; A critical gene in congenital heart disease

Introduction: Congenital heart disease (CHD) affects 1% to 2 % of live births. The Nkx2-5 gene, is known as the significant heart marker during embryonic evolution and it is also necessary for the survival of cardiomyocytes and homeostasis in adulthood. In this study, Nkx2-5 mutations are investigat...

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Bibliographic Details
Main Authors: Samira Kalayinia, Serwa Ghasemi, Nejat Mahdieh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-11-01
Series:Journal of Cardiovascular and Thoracic Research
Subjects:
congenital heart disease
nkx2-5
mutation
computational analysis
Online Access:https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-11-287.pdf

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