Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.
The immortal strand hypothesis poses that stem cells could produce differentiated progeny while conserving the original template strand, thus avoiding accumulating somatic mutations. However, quantitating the extent of non-random DNA strand segregation in human stem cells remains difficult in vivo....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-06-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC6007938?pdf=render |