A novel germline BRCA1 mutation identified in a family with hereditary breast and ovarian cancer syndrome

A novel germline BRCA1 mutation identified in a family with hereditary breast and ovarian cancer syndrome

Pathogenic germline mutations occurring in the BRCA1 (MIM:113705 ) and BRCA2 (MIM: 600185) , which always result in truncated protein or nonsense-mediated mRNA decay, have been identified to increase the risk of hereditary breast, ovarian, pancreatic, prostate, and melanoma cancers. Recent studies s...

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Bibliographic Details
Main Authors:	Yanmei Wu, Xiaodong Pan, Juan Dou, Quan Zhang, Yuantong Li, Yuan Sheng, Xishui Liu
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-06-01
Series:	Clinical Medicine Insights: Oncology
Online Access:	https://doi.org/10.1177/11795549211028569

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