NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

(•)NO is considered to be a key macrophage-derived cytotoxic effector during Trypanosoma cruzi infection. On the other hand, the microbicidal properties of reactive oxygen species (ROS) are well recognized, but little importance has been attributed to them during in vivo infection with T. cruzi. In...

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Bibliographic Details
Main Authors: Helton C Santiago, Claudia Z Gonzalez Lombana, Juan P Macedo, Lara Utsch, Wagner L Tafuri, Maria José Campagnole-Santos, Rosana O Alves, José C F Alves-Filho, Alvaro J Romanha, Fernando Queiroz Cunha, Mauro M Teixeira, Rafael Radi, Leda Q Vieira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3279332?pdf=render

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