The relationship between the spine-pelvis-lower extremity sagittal parameters and disease-related molecules in serum and synovial fluid in patients with knee osteoarthritis

• Main Author: Sheng-Guang Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-06-01
• Series: Journal of Hainan Medical University
• Subjects: Osteoarthritis Spine-pelvis-lower extremity sagittal plane Inflammatory response Apoptosis
• Online Access: http://www.hnykdxxb.com/PDF/201711/22.pdf

Objective: To study the relationship between spine-pelvis-lower extremities sagittal parameters and disease-related molecules in serum and synovial fluid in patients with knee osteoarthritis. Methods: A total of 65 patients diagnosed with knee osteoarthritis in Dongguan Tangxia Hospital between May 2013 and December 2016 were collected as OA group, and 70 patients with meniscus and cruciate ligament injury undergoing repair surgery during the same period were collected as the control group. Spine-pelvis-lower extremity sagittal parameters were measured by erect whole spine lateral radiographs. The serum was collected and inflammatory factor contents were measured. The synovial fluid was collected to determine inflammatory factor contents and apoptosis molecule expression. Results: Affected-side PFA and SFA levels of OA group were significantly lower than those of healthy side while FI and ST levels were significantly higher than those of healthy side; serum TNF-α, IL-1β, IL-18, MMP1 and MMP3 contents of OA group were significantly higher than those of control group, negatively correlated with PFA and SFA levels, and positively correlated with FI and ST levels; TNF-α, IL-1β, IL-18, MMP1, MMP3, Fas, FasL, Caveolin-1, NO, CHOP and GRP78 contents in synovial fluid of OA group were significantly higher than those of control group, negatively correlated with PFA and SFA levels, and positively correlated with FI and ST levels. Conclusion: Sagittal parameters of spine-pelvis-lower extremity can be used to evaluate the inflammatory response and apoptosis in patients with knee osteoarthritis.