High-dose intravenous methotrexate in the management of breast cancer with leptomeningeal disease: Case series and review of the literature

High-dose intravenous methotrexate in the management of breast cancer with leptomeningeal disease: Case series and review of the literature

Leptomeningeal metastasis (LM) in breast cancer is associated with significant morbidity and mortality. While there is currently no standard therapy, treatment options include craniospinal radiotherapy, intrathecal chemotherapy and systemic chemotherapy. Craniospinal radiotherapy has not demonstrate...

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Bibliographic Details
Main Authors: Jonathan T. Kapke, Robert J. Schneidewend, Zeeshan A. Jawa, Chiang-Ching Huang, Jennifer M. Connelly, Christopher R. Chitambar
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387619300792

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