SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction. Here, we identify a critical function for fission yeast STUbL in suppressing spontaneous and...

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Bibliographic Details
Main Authors: Johanna Heideker, John Prudden, J Jefferson P Perry, John A Tainer, Michael N Boddy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3048374?pdf=render

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http://europepmc.org/articles/PMC3048374?pdf=render

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