Optimization and in vivo toxicity evaluation of G4.5 PAMAM dendrimer-risperidone complexes.

Optimization and in vivo toxicity evaluation of G4.5 PAMAM dendrimer-risperidone complexes.

Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein binding (>90%). Since new strategies to improve efficient treatments are...

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Bibliographic Details
Main Authors: Maria Jimena Prieto, Nahuel Eduardo del Rio Zabala, Cristian Hernán Marotta, Hector Carreño Gutierrez, Rosario Arévalo Arévalo, Nadia Silvia Chiaramoni, Silvia del Valle Alonso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938724?pdf=render

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http://europepmc.org/articles/PMC3938724?pdf=render

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