Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretase, a complex consis...

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Main Authors: Wieland Felix T, Placanica Lisa, Nguyen Phuong D, Carter Meghan, Chen Ying, Cheng Haipeng, Bowen James W, Gong Ping, Vetrivel Kulandaivelu S, Li Yue-Ming, Kounnas Maria Z, Thinakaran Gopal
Format: Article
Language:English
Published: BMC 2007-02-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/2/1/4

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http://www.molecularneurodegeneration.com/content/2/1/4

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