Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 t...
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Bibliographic Details
| Main Authors: |
Reza Ghasemi,
Eric Lazear,
Xiaoli Wang,
Saeed Arefanian,
Alexander Zheleznyak,
Beatriz M. Carreno,
Ryuji Higashikubo,
Andrew E. Gelman,
Daniel Kreisel,
Daved H. Fremont,
Alexander Sasha Krupnick |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12878
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