Starved epithelial cells uptake extracellular matrix for survival

Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced...

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Main Authors:	Taru Muranen, Marcin P. Iwanicki, Natasha L. Curry, Julie Hwang, Cory D. DuBois, Jonathan L. Coloff, Daniel S. Hitchcock, Clary B. Clish, Joan S. Brugge, Nada Y. Kalaany
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13989

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spelling	doaj-556105391f034b16b025473af6af65112021-05-11T07:54:39ZengNature Publishing GroupNature Communications2041-17232017-01-018111210.1038/ncomms13989Starved epithelial cells uptake extracellular matrix for survivalTaru Muranen0Marcin P. Iwanicki1Natasha L. Curry2Julie Hwang3Cory D. DuBois4Jonathan L. Coloff5Daniel S. Hitchcock6Clary B. Clish7Joan S. Brugge8Nada Y. Kalaany9Department of Cell Biology, Harvard Medical SchoolDepartment of Cell Biology, Harvard Medical SchoolDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalDepartment of Cell Biology, Harvard Medical SchoolDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalDepartment of Cell Biology, Harvard Medical SchoolBroad Institute of Harvard and MITBroad Institute of Harvard and MITDepartment of Cell Biology, Harvard Medical SchoolDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalInhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced mTORC1 signalling.https://doi.org/10.1038/ncomms13989
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany
spellingShingle	Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany Starved epithelial cells uptake extracellular matrix for survival Nature Communications
author_facet	Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany
author_sort	Taru Muranen
title	Starved epithelial cells uptake extracellular matrix for survival
title_short	Starved epithelial cells uptake extracellular matrix for survival
title_full	Starved epithelial cells uptake extracellular matrix for survival
title_fullStr	Starved epithelial cells uptake extracellular matrix for survival
title_full_unstemmed	Starved epithelial cells uptake extracellular matrix for survival
title_sort	starved epithelial cells uptake extracellular matrix for survival
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced mTORC1 signalling.
url	https://doi.org/10.1038/ncomms13989
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Starved epithelial cells uptake extracellular matrix for survival

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