Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone

The discovery of IDO1 and HDAC1 dual inhibitors may provide a novel strategy for cancer treatment by taking advantages of both immunotherapeutic and epigenetic drugs. In this paper, saprorthoquinone (<b>1</b>) and 13 of its analogues from <i>Salvia prionitis</i> Hance were in...

Full description

Bibliographic Details
Main Authors: Yang Lin, Heyanhao Zhang, Tong Niu, Mei-Lin Tang, Jun Chang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
saprorthoquinone
structural modification
IDO1
HDAC
dual inhibitors
antitumor
Online Access:https://www.mdpi.com/1420-3049/25/19/4494

Internet

https://www.mdpi.com/1420-3049/25/19/4494

Similar Items