A cis-acting element present within the Gag open reading frame negatively impacts on the activity of the HIV-1 IRES.

A cis-acting element present within the Gag open reading frame negatively impacts on the activity of the HIV-1 IRES.

Translation initiation from the human immunodeficiency virus type-1 (HIV-1) mRNA can occur through a cap or an IRES dependent mechanism. Cap-dependent translation initiation of the HIV-1 mRNA can be inhibited by the instability element (INS)-1, a cis-acting regulatory element present within the gag...

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Bibliographic Details
Main Authors: Fernando Valiente-Echeverría, Maricarmen Vallejos, Anne Monette, Karla Pino, Alejandro Letelier, J Pablo Huidobro-Toro, Andrew J Mouland, Marcelo López-Lastra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3581557?pdf=render

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