Modulation of IGF2 Expression in the Murine Thymus and Thymic Epithelial Cells Following Coxsackievirus-B4 Infection

Modulation of IGF2 Expression in the Murine Thymus and Thymic Epithelial Cells Following Coxsackievirus-B4 Infection

Coxsackievirus B4 (CV-B4) can infect human and murine thymic epithelial cells (TECs). In a murine TEC cell line, CV-B4 can downregulate the transcription of the insulin-like growth factor 2 (<i>Igf2</i>) gene coding for the self-peptide of the insulin family. In this study, we show that...

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Bibliographic Details
Main Authors: Hélène Michaux, Aymen Halouani, Charlotte Trussart, Chantal Renard, Hela Jaïdane, Henri Martens, Vincent Geenen, Didier Hober
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Microorganisms
Subjects:
thymus
thymic epithelial cell
type 1 diabetes
coxsackievirus B4
insulin-like growth factor 2
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Online Access:https://www.mdpi.com/2076-2607/9/2/402

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