Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response

Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response

This paper presents computational modeling of response kinetics of bioelectroanalytical system based on the interfacial action of enzyme lipase. The model also assumes that the substrate of enzyme is located on the surface of micelles which are spread in the solution under study. Two distinct mathe...

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Main Authors: M. Puida, F. Ivanauskas, I. Ignatjev, G. Valinčius, V. Razumas
Format: Article
Language:English
Published: Vilnius University Press 2007-04-01
Series:Nonlinear Analysis
Subjects:
computer simulation
biosensors
amperometric bioanalytical system
Online Access:http://www.zurnalai.vu.lt/nonlinear-analysis/article/view/14714
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spelling doaj-553c36d9f6c84685a8871e50ed96bba22020-11-25T01:32:13ZengVilnius University PressNonlinear Analysis1392-51132335-89632007-04-0112210.15388/NA.2007.12.2.14714Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent ResponseM. Puida0F. Ivanauskas1I. Ignatjev2G. Valinčius3V. Razumas4Vilnius University, LithuaniaVilnius University, Lithuania; Institute of Mathematics and Informatics, LithuaniaInstitute of Biochemistry, LithuaniaInstitute of Biochemistry, LithuaniaInstitute of Biochemistry, Lithuania This paper presents computational modeling of response kinetics of bioelectroanalytical system based on the interfacial action of enzyme lipase. The model also assumes that the substrate of enzyme is located on the surface of micelles which are spread in the solution under study. Two distinct mathematical models have been developed and evaluated through computational simulation series. The results of simulation demonstrate that diffusion is important factor for the sensitivity of bioelectroanalytical system, and it is important to take this process of mass transfer into account in all system areas. http://www.zurnalai.vu.lt/nonlinear-analysis/article/view/14714computer simulationbiosensorsamperometric bioanalytical system
collection DOAJ
language English
format Article
sources DOAJ
author M. Puida
F. Ivanauskas
I. Ignatjev
G. Valinčius
V. Razumas
spellingShingle M. Puida
F. Ivanauskas
I. Ignatjev
G. Valinčius
V. Razumas
Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
Nonlinear Analysis
computer simulation
biosensors
amperometric bioanalytical system
author_facet M. Puida
F. Ivanauskas
I. Ignatjev
G. Valinčius
V. Razumas
author_sort M. Puida
title Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
title_short Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
title_full Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
title_fullStr Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
title_full_unstemmed Computational Modeling of the Amperometric Bioanalytical System for Lipase Activity Assay: a Time-Dependent Response
title_sort computational modeling of the amperometric bioanalytical system for lipase activity assay: a time-dependent response
publisher Vilnius University Press
series Nonlinear Analysis
issn 1392-5113
2335-8963
publishDate 2007-04-01
description This paper presents computational modeling of response kinetics of bioelectroanalytical system based on the interfacial action of enzyme lipase. The model also assumes that the substrate of enzyme is located on the surface of micelles which are spread in the solution under study. Two distinct mathematical models have been developed and evaluated through computational simulation series. The results of simulation demonstrate that diffusion is important factor for the sensitivity of bioelectroanalytical system, and it is important to take this process of mass transfer into account in all system areas.
topic computer simulation
biosensors
amperometric bioanalytical system
url http://www.zurnalai.vu.lt/nonlinear-analysis/article/view/14714
work_keys_str_mv AT mpuida computationalmodelingoftheamperometricbioanalyticalsystemforlipaseactivityassayatimedependentresponse
AT fivanauskas computationalmodelingoftheamperometricbioanalyticalsystemforlipaseactivityassayatimedependentresponse
AT iignatjev computationalmodelingoftheamperometricbioanalyticalsystemforlipaseactivityassayatimedependentresponse
AT gvalincius computationalmodelingoftheamperometricbioanalyticalsystemforlipaseactivityassayatimedependentresponse
AT vrazumas computationalmodelingoftheamperometricbioanalyticalsystemforlipaseactivityassayatimedependentresponse
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