Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures

Captopril is an angiotensin-converting enzyme (ACE) inhibitor that is used for the treatment of hypertension and congestive heart failure. This article addresses the accurate measurements of densities and refractive indices of solutions containing captopril in pure solvents such as water, methanol,...

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Main Authors: Santosh D. Deosarkar, Meenakshi P. Pawar, Atmaram D. Arsule, Rajendrakumar T. Sawale, Tukaram M. Kalyankar
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:Journal of Taibah University for Science
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1658365517300262
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spelling doaj-552c3cc1c0e043579d543ba6761ad2582020-11-25T00:18:23ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552017-09-0111581582110.1016/j.jtusci.2017.02.003Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixturesSantosh D. Deosarkar0Meenakshi P. Pawar1Atmaram D. Arsule2Rajendrakumar T. Sawale3Tukaram M. Kalyankar4School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, MS, IndiaSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, MS, IndiaSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, MS, IndiaSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, MS, IndiaSchool of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded 431 606, MS, IndiaCaptopril is an angiotensin-converting enzyme (ACE) inhibitor that is used for the treatment of hypertension and congestive heart failure. This article addresses the accurate measurements of densities and refractive indices of solutions containing captopril in pure solvents such as water, methanol, ethanol and 1-propanol and aqueous mixtures of methanol, ethanol and propan-1-ol of 30%, 50% and 70% by volume in a wide range of drug concentration at 26 °C. This article also includes the evaluation of apparent molar volume, partial molar volume at infinite dilution and transfer volumes. The concentration dependence of the refractive indices studied and respective fitting parameters have been reported. Different properties are interpreted in terms of intermolecular interactions, effect of drug on structure of solvent/solvent mixture and overall structural fittings in solutions.http://www.sciencedirect.com/science/article/pii/S1658365517300262DrugSolvationMolecular interactionsAlcohols
collection DOAJ
language English
format Article
sources DOAJ
author Santosh D. Deosarkar
Meenakshi P. Pawar
Atmaram D. Arsule
Rajendrakumar T. Sawale
Tukaram M. Kalyankar
spellingShingle Santosh D. Deosarkar
Meenakshi P. Pawar
Atmaram D. Arsule
Rajendrakumar T. Sawale
Tukaram M. Kalyankar
Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
Journal of Taibah University for Science
Drug
Solvation
Molecular interactions
Alcohols
author_facet Santosh D. Deosarkar
Meenakshi P. Pawar
Atmaram D. Arsule
Rajendrakumar T. Sawale
Tukaram M. Kalyankar
author_sort Santosh D. Deosarkar
title Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
title_short Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
title_full Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
title_fullStr Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
title_full_unstemmed Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures
title_sort volumetric and optical properties of ace inhibitor captopril in aqueous-alcoholic mixtures
publisher Taylor & Francis Group
series Journal of Taibah University for Science
issn 1658-3655
publishDate 2017-09-01
description Captopril is an angiotensin-converting enzyme (ACE) inhibitor that is used for the treatment of hypertension and congestive heart failure. This article addresses the accurate measurements of densities and refractive indices of solutions containing captopril in pure solvents such as water, methanol, ethanol and 1-propanol and aqueous mixtures of methanol, ethanol and propan-1-ol of 30%, 50% and 70% by volume in a wide range of drug concentration at 26 °C. This article also includes the evaluation of apparent molar volume, partial molar volume at infinite dilution and transfer volumes. The concentration dependence of the refractive indices studied and respective fitting parameters have been reported. Different properties are interpreted in terms of intermolecular interactions, effect of drug on structure of solvent/solvent mixture and overall structural fittings in solutions.
topic Drug
Solvation
Molecular interactions
Alcohols
url http://www.sciencedirect.com/science/article/pii/S1658365517300262
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