Study of Anti-Chlamydia pneumoniae IgG and IgM, and risk factors in suspected cardiac ischemic,s refered to Shahid Madany angioghraphy center, Khorramabad

• Main Authors: hasan Hossainzadegan, babak Baharvand, mahnaz Mardani, farzad Ebrahimzadeh, mohammad mehdi Gadiri
• Format: Article
• Language: fas
• Published: Lorestan University of Medical Science 2009-04-01
• Series: Yafteh
• Subjects: Atherosclerosis; Chlamydia pneumonia; Angiography; Coronary artery disease
• Online Access: http://yafte.lums.ac.ir/browse.php?a_code=A-10-1-97&slc_lang=en&sid=1

Background: Considering the high morbidity and mortality of atherosclerosis and the coronary artery disease in the world, this study aimed to investigate the roles of different risk factors in the suspected patients referring to Shahid Madani angiography center in Khorramabad. Materials and Methods: The referred patients suspected to heart diseases were divided into the afflicted group, as well as the seemingly healthy group by angiography. The demographic and nutritional information of the studied groups were collected by a questionnaire, and the anti-Chlamydia pneumonia IgG and IgM antibodies, lipids, the rheumatoid factor, C-reactive protein, and anti-Streptolysin were measured in the serums of the patients. Data were analyzed using T-test and χ2. Results: 120 cases out of 380 were excluded from the study because of confounding information. Additionally, 169 and 91 cases of the remaining 260 studied ones were diagnosed as afflicted and seemingly healthy by angiography respectively. Moreover, 101 (70.6%) and 68 (58%) of the 169 patients were males and females respectively. The highest number of the patients aged between 50 to 60 years old, while the highest affliction rate was among the patients in the age range of 40 to 50 (69.8%). The highest rate of affliction with the disease was among the patients with the blood type A. One hundred percent of the referred persons were employees, as well as 75.5% of the cases were stockbreeder who suffered from the disease. There were statistically significant relationships between fruit as well as very low and high meat consumption and heart diseases in the two groups. The serology results indicated that 87.5 % of the cases with anti-Chlamydia pneumonia IgM suffered from heart diseases. Conclusion: The high frequency of the coronary artery disease in the persons that had the positive titer of anti-Chlamydia pneumonia IgM suggests a possible relation of active or recurrent infection with the disease. On the other hand, it is likely that the nutritional patterns of the studied cases also had a relationship with the coronary artery disease. Therefore, the coronary artery disease possibly had a relationship with the microbial and nutritional risk factors of the studied persons in the case group. However, further studies are definitely needed in this regard.