The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which could yield plasma concentrations that may be suffi...

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Bibliographic Details
Main Authors: Simone Bærentzen, Agata Casado-Sainz, Denise Lange, Vladimir Shalgunov, Isabel Martinez Tejada, Mengfei Xiong, Elina T. L’Estrade, Fraser G. Edgar, Hedok Lee, Matthias M. Herth, Mikael Palner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
DREADD
CNO
clozapine
dopamine receptors
serotonin receptors
glutamate
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00187/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00187/full

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