Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
The BRICHOS domain is a chaperone that can act against amyloid-β peptide fibril formation and non-fibrillar protein aggregation. Here the authors use a multidisciplinary approach and show that the Bri2 BRICHOS domain has qualitatively different chaperone activities depending on its quaternary struct...
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Bibliographic Details
| Main Authors: |
Gefei Chen,
Axel Abelein,
Harriet E. Nilsson,
Axel Leppert,
Yuniesky Andrade-Talavera,
Simone Tambaro,
Lovisa Hemmingsson,
Firoz Roshan,
Michael Landreh,
Henrik Biverstål,
Philip J. B. Koeck,
Jenny Presto,
Hans Hebert,
André Fisahn,
Jan Johansson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02056-4
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