Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination

Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination

An ultra-high performance liquid chromatography method for simultaneous determination of tacrolimus impurities in pharmaceutical dosage forms has been developed. Appropriate chromatographic separation was achieved on a BEH C18 column using gradient elution with a total run time of 14 min. The method...

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Bibliographic Details
Main Authors: Peterka Tanja Rozman, Lušin Tina Trdan, Bergles Jure, Ham Zoran, Grahek Rok, Urleb Uroš
Format: Article
Language:English
Published: Sciendo 2019-09-01
Series:Acta Pharmaceutica
Subjects:
tacrolimus
forced degradation
uhplc
impurities
stability
Online Access:https://doi.org/10.2478/acph-2019-0025

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