Symptomatic primary hyperparathyroidism in a young woman presenting with multiple skeletal destructions: a case report and review of literature

• Main Authors: Shuai Lu, Maoqi Gong, Yejun Zha, Aimin Cui, Wei Tian, Xieyuan Jiang
• Format: Article
• Language: English
• Published: BMC 2021-01-01
• Series: BMC Endocrine Disorders
• Subjects: Hyperparathyroidism; Multiple skeletal destructions; Case report
• Online Access: https://doi.org/10.1186/s12902-020-00669-3

Abstract Background Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Here we described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals. Case presentation A 30-year-old woman was admitted to our hospital due to pain in both knees and walking difficulty that lasted for 6 and 2 years, respectively. Her laboratory test results revealed a high parathyroid hormone level (822 pg/ml) and hypercalcemia (2.52 mmol/L) in the blood. Parathyroid imaging revealed a lumpy concentration of radioactive uptake detected at the lower pole in the right lobe of the thyroid, and was nearly 2.2 cm * 2.4 cm in size. Next, the patient was treated with parathyroidectomy that resulted in a significant improvement in physiological and clinical symptoms. Moreover, the skeletal destruction and bone mineral density were significantly improved after a 5-years follow-up period. Conclusions Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions.