Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds

Objective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of th...

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Main Authors: Andrey Vyshedskiy, Raymond Murphy
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Pulmonary Medicine
Online Access:http://dx.doi.org/10.1155/2012/139395
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spelling doaj-54dd31838a484841a3f46bbe87363ad32020-11-25T00:31:08ZengHindawi LimitedPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/139395139395Pendelluft in Chronic Obstructive Lung Disease Measured with Lung SoundsAndrey Vyshedskiy0Raymond Murphy1Brigham and Women's, Faulkner Hospital, Boston, MA 02130, USABrigham and Women's, Faulkner Hospital, Boston, MA 02130, USAObjective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of this study was to apply the method of lung sounds mapping, which is known to provide regional information about gas flow, to study pendelluft in COPD patients. Methods. A 16-channel lung sound analyzer was used to collect sounds from patients with COPD (n=90) and age-matched normals (n=90). Pendelluft at the beginning of inspiration is expected to result in vesicular sounds leading the tracheal sound by a few milliseconds. Pendelluft at the end of inspiration is expected to result in vesicular sounds lagging the tracheal sound. These lead and lag times were calculated for the 14 chest wall sites. Results. The lead time was significantly longer in COPD patients: 123±107 ms versus 48±59 ms in controls (P<0.0001). The lag time was also significantly longer in COPD patients: 269±249 ms in COPD patients versus 147±124 ms in controls (P<0.0001). When normalized by the duration of the inspiration at the trachea, the lead was 14±13% for COPD versus 4±5% for controls (P<0.0001). The lag was 28±25% for COPD versus 13±12% for controls (P<0.0001). Both lead and lag correlated moderately with the GOLD stage (correlation coefficient 0.43). Conclusion. Increased lead and lag times in COPD patients are consistent with the phenomenon of pendelluft as has been observed by other methods.http://dx.doi.org/10.1155/2012/139395
collection DOAJ
language English
format Article
sources DOAJ
author Andrey Vyshedskiy
Raymond Murphy
spellingShingle Andrey Vyshedskiy
Raymond Murphy
Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
Pulmonary Medicine
author_facet Andrey Vyshedskiy
Raymond Murphy
author_sort Andrey Vyshedskiy
title Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
title_short Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
title_full Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
title_fullStr Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
title_full_unstemmed Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
title_sort pendelluft in chronic obstructive lung disease measured with lung sounds
publisher Hindawi Limited
series Pulmonary Medicine
issn 2090-1836
2090-1844
publishDate 2012-01-01
description Objective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of this study was to apply the method of lung sounds mapping, which is known to provide regional information about gas flow, to study pendelluft in COPD patients. Methods. A 16-channel lung sound analyzer was used to collect sounds from patients with COPD (n=90) and age-matched normals (n=90). Pendelluft at the beginning of inspiration is expected to result in vesicular sounds leading the tracheal sound by a few milliseconds. Pendelluft at the end of inspiration is expected to result in vesicular sounds lagging the tracheal sound. These lead and lag times were calculated for the 14 chest wall sites. Results. The lead time was significantly longer in COPD patients: 123±107 ms versus 48±59 ms in controls (P<0.0001). The lag time was also significantly longer in COPD patients: 269±249 ms in COPD patients versus 147±124 ms in controls (P<0.0001). When normalized by the duration of the inspiration at the trachea, the lead was 14±13% for COPD versus 4±5% for controls (P<0.0001). The lag was 28±25% for COPD versus 13±12% for controls (P<0.0001). Both lead and lag correlated moderately with the GOLD stage (correlation coefficient 0.43). Conclusion. Increased lead and lag times in COPD patients are consistent with the phenomenon of pendelluft as has been observed by other methods.
url http://dx.doi.org/10.1155/2012/139395
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