MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart.

MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart.

MicroRNA-208a (mir-208a) is essential for cardiac hypertrophy and fibrosis. Endoglin, a co-receptor of transforming growth factor-β is also essential for cardiac fibrosis. Endoglin has been shown to be a target of mir-208a in the in vitro mechanical stress model. Volume overload can lead to heart fa...

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Bibliographic Details
Main Authors: Bao-Wei Wang, Gong-Jhe Wu, Wen-Ping Cheng, Kou-Gi Shyu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3879305?pdf=render

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