Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo

• Main Authors: Hilmi Islami, Sadi Bexheti, Halil Ahmetaj, Aziz Šukalo, Suzana Manxhuka, Bajram Nuraj, Xhevat Kamberi, Shaip Krasniqi, Hasime Qorraj, Bashkim Kastrati, Mentor Disha
• Format: Article
• Language: English
• Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2009-05-01
• Series: Bosnian Journal of Basic Medical Sciences
• Subjects: Trachea; ACh; propranolol; histamine; 5-HT and PGF2-alfa
• Online Access: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2834

Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm3 were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).