Mucin-secreting gastric adenocarcinoma with Rhabdoid areas

• Main Authors: Sharma Sonal, Gupta Richa, Sharma Rajeev, Kotru Mrinalini
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: The Saudi Journal of Gastroenterology
• Subjects: Gastric adenocarcinoma; rhabdoid; immunohistochemistry; prognosis
• Online Access: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=1;spage=46;epage=48;aulast=Sharma

Rhabdoid tumor, first described in kidneys of infants and children, is an aggressive tumor that has been reported in several extrarenal locations. In this report, we describe the case of a 40-year-old patient with gastric adenocarcinoma composed of histologically well-differentiated glandular areas and focal rhabdoid zones. The rhabdoid component showed typical features such as abundant eosinophilic cytoplasm, eccentric nuclei, prominent nucleoli and intense focal positive immunohistochemical cytoplasmic reaction for vimentin. Recognition of the rhabdoid phenotype in gastrointestinal tract neoplasms is important because this feature is associated with poor prognosis and unresponsiveness to conventional therapy.