Preparation of the Phencyclidine Analogues (Part II)

Preparation of the Phencyclidine Analogues (Part II)

Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3C...

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Main Authors: Mohammad Raouf Darvich, Afsaneh Zonoozi
Format: Article
Language:English
Published: Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 1993-06-01
Series:Iranian Journal of Chemistry & Chemical Engineering
Online Access:http://www.ijcce.ac.ir/article_10929_d41d8cd98f00b204e9800998ecf8427e.pdf
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spelling doaj-54c9f01b4b734dc98676794cd1357b5b2020-11-25T03:26:02ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering 1021-99861021-99861993-06-01121172110929Preparation of the Phencyclidine Analogues (Part II)Mohammad Raouf Darvich0Afsaneh Zonoozi1Department of Chemistry, Faculty of Science, Tehran University, Tehran, I.R. IRANDepartment of Chemistry, Faculty of Science, Tehran University, Tehran, I.R. IRANUsing a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3COOH in CHCl3. The azides were subsequently reduced with LiAlH4 in dry ether to their primary amines. Cyclization of these amines with 1,5-dibromopentane and 1,4- dibromobutane gave tertiary amines.http://www.ijcce.ac.ir/article_10929_d41d8cd98f00b204e9800998ecf8427e.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Raouf Darvich
Afsaneh Zonoozi
spellingShingle Mohammad Raouf Darvich
Afsaneh Zonoozi
Preparation of the Phencyclidine Analogues (Part II)
Iranian Journal of Chemistry & Chemical Engineering
author_facet Mohammad Raouf Darvich
Afsaneh Zonoozi
author_sort Mohammad Raouf Darvich
title Preparation of the Phencyclidine Analogues (Part II)
title_short Preparation of the Phencyclidine Analogues (Part II)
title_full Preparation of the Phencyclidine Analogues (Part II)
title_fullStr Preparation of the Phencyclidine Analogues (Part II)
title_full_unstemmed Preparation of the Phencyclidine Analogues (Part II)
title_sort preparation of the phencyclidine analogues (part ii)
publisher Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
series Iranian Journal of Chemistry & Chemical Engineering
issn 1021-9986
1021-9986
publishDate 1993-06-01
description Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3COOH in CHCl3. The azides were subsequently reduced with LiAlH4 in dry ether to their primary amines. Cyclization of these amines with 1,5-dibromopentane and 1,4- dibromobutane gave tertiary amines.
url http://www.ijcce.ac.ir/article_10929_d41d8cd98f00b204e9800998ecf8427e.pdf
work_keys_str_mv AT mohammadraoufdarvich preparationofthephencyclidineanaloguespartii
AT afsanehzonoozi preparationofthephencyclidineanaloguespartii
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