Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved thro...

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Main Authors: M.Z. Rizk, D.M. Abo-El-matty, H.F. Aly, H.I. Abd-Alla, S.M. Saleh, E.A. Younis, A.M. Elnahrawy, A.A. Haroun
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Toxicology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750018303573
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spelling doaj-54c8b93a3c004b048d2b039a6adc3b6e2020-11-24T21:46:51ZengElsevierToxicology Reports2214-75002018-01-015929942Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicityM.Z. Rizk0D.M. Abo-El-matty1H.F. Aly2H.I. Abd-Alla3S.M. Saleh4E.A. Younis5A.M. Elnahrawy6A.A. Haroun7Therapeutic Chemistry Department, National Research Centre, Dokki12622, Giza, EgyptBiochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismalia, EgyptTherapeutic Chemistry Department, National Research Centre, Dokki12622, Giza, Egypt; Corresponding author.Chemistry of Natural Compounds Department, National Research Centre, Dokki12622, Giza, EgyptBiochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismalia, EgyptTherapeutic Chemistry Department, National Research Centre, Dokki12622, Giza, EgyptDepartment of Solid State Physics, National Research Centre, Dokki 12622,Giza, EgyptChemical Industries Res Division, National Research Centre, Dokki12622, Giza, EgyptThe current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved through measuring the activities of specific biochemical parameters related to liver functions in tissue of ACR intoxicated rats as compared to normal one. Liver functions included alanine and aspartate aminotransferases, antioxidants and oxidative stress biomarkers; superoxide dismutase, catalase, glutathione and lipid peroxide (malondialdehyde, MDA). Moreover, histological examination of liver was performed to confirm the biochemical findings. The present results clearly indicated disturbances in all biochemical parameters, such as increase in the liver function enzyme activities and MDA level. Results of ATPase enzyme activities revealed significant decrease in ACR intoxicated rats and liver biomarker enzymes declared significant decrease. On the other hand, treatment of intoxicated rats with the previous different nano-particles natural product demonstrated improvement in all biochemical parameters under investigation. Keywords: Sour orange albedo, Flavanones, acrylamide, Nanocomposites, Liver biochemical parameters, Histopathologyhttp://www.sciencedirect.com/science/article/pii/S2214750018303573
collection DOAJ
language English
format Article
sources DOAJ
author M.Z. Rizk
D.M. Abo-El-matty
H.F. Aly
H.I. Abd-Alla
S.M. Saleh
E.A. Younis
A.M. Elnahrawy
A.A. Haroun
spellingShingle M.Z. Rizk
D.M. Abo-El-matty
H.F. Aly
H.I. Abd-Alla
S.M. Saleh
E.A. Younis
A.M. Elnahrawy
A.A. Haroun
Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
Toxicology Reports
author_facet M.Z. Rizk
D.M. Abo-El-matty
H.F. Aly
H.I. Abd-Alla
S.M. Saleh
E.A. Younis
A.M. Elnahrawy
A.A. Haroun
author_sort M.Z. Rizk
title Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_short Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_full Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_fullStr Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_full_unstemmed Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_sort therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
publisher Elsevier
series Toxicology Reports
issn 2214-7500
publishDate 2018-01-01
description The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved through measuring the activities of specific biochemical parameters related to liver functions in tissue of ACR intoxicated rats as compared to normal one. Liver functions included alanine and aspartate aminotransferases, antioxidants and oxidative stress biomarkers; superoxide dismutase, catalase, glutathione and lipid peroxide (malondialdehyde, MDA). Moreover, histological examination of liver was performed to confirm the biochemical findings. The present results clearly indicated disturbances in all biochemical parameters, such as increase in the liver function enzyme activities and MDA level. Results of ATPase enzyme activities revealed significant decrease in ACR intoxicated rats and liver biomarker enzymes declared significant decrease. On the other hand, treatment of intoxicated rats with the previous different nano-particles natural product demonstrated improvement in all biochemical parameters under investigation. Keywords: Sour orange albedo, Flavanones, acrylamide, Nanocomposites, Liver biochemical parameters, Histopathology
url http://www.sciencedirect.com/science/article/pii/S2214750018303573
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