Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice

Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice

Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal treatment efficacy. Despite the severity of this...

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Bibliographic Details
Main Authors: Jessica Cedervall, Anca Dragomir, Falk Saupe, Yanyu Zhang, Johan Ärnlöv, Erik Larsson, Anna Dimberg, Anders Larsson, Anna-Karin Olsson
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
cancer
dnase i
gsk484
kidney injury
neutrophil extracellular traps
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1320009

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