Effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats

• Main Authors: Parham Reisi, Hojjatallah Alaei, Shirin Babri, Mohammad Reza Sharifi, Gisue Mohaddes, Elaheh Soleimannejad, Bahman Rashidi
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Research in Medical Sciences
• Subjects: Diabetes; Glutamate; GABA; Dentate Gyrus; Treadmill Running; Microdialysis; Hippocampus; Streptozotocin
• Online Access: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2010;volume=15;issue=3;spage=172;epage=174;aulast=Reisi

Background: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats. Methods: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated. Results: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups. Conclusions: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.