Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Abstract Background Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagoni...

Full description

Bibliographic Details
Main Authors: Shikhar Mehta, Sumayyah Akhtar, Ryan M. Porter, Patrik Önnerfjord, Ambika G. Bajpayee
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Arthritis Research & Therapy
Subjects:
IL-1Ra
IL-1
Cartilage-synovium co-culture
Crosstalk
Sustained dose
Nitric oxide
Online Access:http://link.springer.com/article/10.1186/s13075-019-2003-y

Internet

http://link.springer.com/article/10.1186/s13075-019-2003-y

Similar Items