Development of a Novel SPR Assay to Study CXCR4–Ligand Interactions

Development of a Novel SPR Assay to Study CXCR4–Ligand Interactions

G protein-coupled receptors (GPCRs) are involved in a plethora of different diseases. Consequently, these proteins are considered as an important class of drug targets. Measuring detailed kinetic information on these types of proteins has been challenging. Surface plasmon resonance (SPR) can provide...

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Bibliographic Details
Main Authors: Arnaud Boonen, Abhimanyu K. Singh, Anneleen Van Hout, Kalyan Das, Tom Van Loy, Sam Noppen, Dominique Schols
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biosensors
Subjects:
surface plasmon resonance
G protein-coupled receptors
CXCR4
histidine tag
nanobodies
kinetics
Online Access:https://www.mdpi.com/2079-6374/10/10/150

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