Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies

Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies

Abstract Background Cancerous cells can recycle metabolic ammonium for their growth. As this ammonium has a low nitrogen isotope ratio (15N/14N), its recycling may cause cancer tissue to have lower 15N/14N than surrounding healthy tissue. We investigated whether, within a given tissue type in indivi...

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Bibliographic Details
Main Authors: M. Straub, D. M. Sigman, A. Auderset, J. Ollivier, B. Petit, B. Hinnenberg, F. Rubach, S. Oleynik, M.-C. Vozenin, A. Martínez-García
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Cancer
Subjects:
Micro-biopsies
Diagnostics
Cell metabolism
Nitrogen isotopes
Online Access:https://doi.org/10.1186/s12885-021-08489-x

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