Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome

Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome

Abstract Background Trisomy 18 syndrome (Edwards syndrome, ES) is a type of aneuploidy caused by the presence of an extra chromosome 18. Aneuploidy is the leading cause of early pregnancy loss, intellectual disability, and multiple congenital anomalies. The research of trisomy 18 is progressing slow...

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Bibliographic Details
Main Authors: Xiaofen Qiu, Haiyan Yu, Hongwei Wu, Zhiyang Hu, Jun Zhou, Hua Lin, Wen Xue, Wanxia Cai, Jiejing Chen, Qiang Yan, Weier Dai, Ming Yang, Donge Tang, Yong Dai
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Human Genomics
Subjects:
Trisomy 18 syndrome
single-cell sequencing
Transcription factors
Aneuploidy
Developmental regulation
Online Access:https://doi.org/10.1186/s40246-021-00338-z

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