Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points

Summary: Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and c...

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Main Authors:	Amin Mahpour, Alan C. Mullen
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	JHEP Reports
Subjects:	lncRNA Liver-specific lncRNAs Liver fibrosis Liver cancer Hepatocellular carcinoma Cholangiocarcinoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589555920301117

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spelling	doaj-54a844987d7e46cca6fb5031be6da0e12021-02-07T04:24:48ZengElsevierJHEP Reports2589-55592021-02-0131100177Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey pointsAmin Mahpour0Alan C. Mullen1Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USAGastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Corresponding author. Address: Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.Summary: Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.http://www.sciencedirect.com/science/article/pii/S2589555920301117lncRNALiver-specific lncRNAsLiver fibrosisLiver cancerHepatocellular carcinomaCholangiocarcinoma
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amin Mahpour Alan C. Mullen
spellingShingle	Amin Mahpour Alan C. Mullen Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points JHEP Reports lncRNA Liver-specific lncRNAs Liver fibrosis Liver cancer Hepatocellular carcinoma Cholangiocarcinoma
author_facet	Amin Mahpour Alan C. Mullen
author_sort	Amin Mahpour
title	Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points
title_short	Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points
title_full	Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points
title_fullStr	Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points
title_full_unstemmed	Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points
title_sort	our emerging understanding of the roles of long non-coding rnas in normal liver function, disease, and malignancykey points
publisher	Elsevier
series	JHEP Reports
issn	2589-5559
publishDate	2021-02-01
description	Summary: Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.
topic	lncRNA Liver-specific lncRNAs Liver fibrosis Liver cancer Hepatocellular carcinoma Cholangiocarcinoma
url	http://www.sciencedirect.com/science/article/pii/S2589555920301117
work_keys_str_mv	AT aminmahpour ouremergingunderstandingoftherolesoflongnoncodingrnasinnormalliverfunctiondiseaseandmalignancykeypoints AT alancmullen ouremergingunderstandingoftherolesoflongnoncodingrnasinnormalliverfunctiondiseaseandmalignancykeypoints
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Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points

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