Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology

Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology

Nω-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) biosynthesis, results in hypertension and liver injury. This study aimed at investigating the changes of liver lipometabonomics and exploring the underlying mechanisms of liver injury in the L-NAME-treated rats. The male Sp...

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Bibliographic Details
Main Authors: Bo Li, Xinglishang He, Shan-Shan Lei, Fu-Chen Zhou, Ning-Yu Zhang, Ye-Hui Chen, Yu-Zhi Wang, Jie Su, Jing-Jing Yu, Lin-Zi Li, Xiang Zheng, Rong Luo, Dorota Kołodyńska, Shan Xiong, Gui-Yuan Lv, Su-Hong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
hypertension
liver injury
multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL)
fatty acid
intestinal pathophysiology
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01677/full

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