A linearized non-isothermal general rate model for studying thermal effects in liquid chromatographic columns
A linearized non-isothermal general rate model is formulated and analytically solved to quantify the effects of temperature variations in fixed-bed chromatographic columns. The model contains a set of four coupled PDE accounting for energy transfer resistances, inner and outer particle-pore diffusio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
VINCA Institute of Nuclear Sciences
2021-01-01
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| Series: | Thermal Science |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-9836/2021/0354-98362000336K.pdf |
| Summary: | A linearized non-isothermal general rate model is formulated and analytically solved to quantify the effects of temperature variations in fixed-bed chromatographic columns. The model contains a set of four coupled PDE accounting for energy transfer resistances, inner and outer particle-pore diffusions, and interfacial mass and axial dispersion. The Laplace transform, the eigenvalue-decomposition technique, and a conventional technique for the solutions of ODE are jointly employed for the solution of the model equations. A few numerical test studies are considered to assess the impact of system parameters on the performance of packed-bed adsorption columns. To access the range of applicability and to get the scope of the appropriateness of calculated analytical results, the numerical results are also obtained by applying a high resolution finite volume scheme. The analytical solutions obtained can be used as an invaluable tool for analyzing, optimizing, and upgrading the non-isothermal liquid chromatographic procedures. |
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| ISSN: | 0354-9836 2334-7163 |