Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this pathway in the regulation of T-cell-mediated central nervous system (CNS) autoimmune inflammation, such as in experimental autoimmune encephalomyelitis (EAE), remains unclear. It is a...

Full description

Bibliographic Details
Main Authors: Tatyana Veremeyko, Amanda W. Y. Yung, Marina Dukhinova, Inna S. Kuznetsova, Igor Pomytkin, Alexey Lyundup, Tatyana Strekalova, Natasha S. Barteneva, Eugene D. Ponomarev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
Th1 cells
neuroinflammation
Forskolin
cAMP
microRNA-124
macrophage
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00050/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00050/full

Similar Items