Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Non-Malignant Nodular Goiter

• Main Authors: Rabiee A, Salman M, Tourky M, Ameen M, Hussein A, Salman A, Labib S, Soliman AAZA, Shaaban HE, GabAllah G, Abouelregal T
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-06-01
• Series: International Journal of General Medicine
• Subjects: antithyroid antibodies; total thyroidectomy
• Online Access: https://www.dovepress.com/antithyroid-peroxidase-antibodies-and-histopathological-outcomes-in-eg-peer-reviewed-fulltext-article-IJGM
• ISSN: 1178-7074

Ahmed Rabiee,1 Mohamed Salman,2 Mohamed Tourky,3 Mahmoud Ameen,2 Ahmed Hussein,2 Ahmed Salman,1 Safa Labib,1 Ahmed Abdulkader Zaki Ali Soliman,4 Hossam El-Din Shaaban,5 Ghada GabAllah,6 Tarek Abouelregal1 1Internal Medicine Department, Kasralainy School of Medicine, Cairo University, Cairo, Egypt; 2General Surgery Department, Kasralainy School of Medicine, Cairo University, Cairo, Egypt; 3Great Western Hospital, NHS Foundation Trust, Swindon, UK; 4Lancashire Teaching Hospital, NHS Foundation, Preston, UK; 5Gastroenterology and Hepatology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 6Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Menoufia, EgyptCorrespondence: Mohamed SalmanGeneral Surgery Department, Kasralainy School of Medicine, Cairo University, Cairo, EgyptEmail [e-mail] TourkyGreat Western Hospital, NHS Foundation Trust, Marlborough Road, Swindon, SN3 6BB, UKEmail [e-mail]: The study aimed to assess antithyroid antibodies in patients with benign thyroid masses and the effect of total thyroidectomy on the antibodies titers.Patients and Methods: This is a retrospective work of 112 cases managed with total thyroidectomy with positive antithyroid peroxidase antibodies (TPO-Ab), anti-thyroglobulin antibodies (Tg-Ab), or both. All patients were euthyroid before surgery. Thyroid function tests and thyroid antibodies levels were measured before and 6 and 12 months after surgery.Results: Histopathological evaluation revealed Hashimoto thyroiditis (47.3%), colloid nodules (22.3%), and lymphocytic thyroiditis (30.4%). All patients were TPO-Ab positive, while 96 patients (85.7%) were Tg-Ab positive before surgery. There was no considerable change in TPO-Ab and Tg-Ab after surgery (p = 0.817, and p=0.560, respectively). Also, there was no significant difference between the three histopathological diagnoses in the levels of TPO-Ab (p = 0.086) or Tg-Ab (p = 0.673).Conclusion: Antithyroid antibodies are not valuable markers for diagnosis or prognosis of benign thyroid diseases subjected to total thyroidectomy. We do not recommend their use beyond supporting evidence of the possibility of the autoimmune nature of the illness if other criteria are confirmed.Keywords: antithyroid antibodies, total thyroidectomy