Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones

A variety of different novel functionalized ferrocenyl chalcone and organic chalcone based sulfones and bis-sulfones were synthesized in excellent yield under mild reaction condition. The antimicrobial activities as bactericide and fungicide were evaluated for all the synthesized compounds and struc...

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Main Authors:	Naseem Ahmed, Naveen Kumar Konduru, Mohammad Owais
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Series:	Arabian Journal of Chemistry
Online Access:	http://www.sciencedirect.com/science/article/pii/S187853521400358X

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spelling	doaj-548a021c46d943fab52ba165ee5ff8f02020-11-25T02:45:28ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112818791894Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfonesNaseem Ahmed0Naveen Kumar Konduru1Mohammad Owais2Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, India; Corresponding author. Tel./fax: +91 1332 285745.Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, IndiaInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, IndiaA variety of different novel functionalized ferrocenyl chalcone and organic chalcone based sulfones and bis-sulfones were synthesized in excellent yield under mild reaction condition. The antimicrobial activities as bactericide and fungicide were evaluated for all the synthesized compounds and structure–activity relationships were established. Many compounds exhibited high and broad-range bactericidal activity. Among them, organic chalcone based on nitro-substituted 4c and chloro-substituted 6c, ferrocenyl chalcone based trimethoxy-substituted 20c and dimethyl-substituted 24c molecules displayed the best and broad-range bactericidal activity. Product 24c also exhibited the highest antifungal activity against most of the fungi tested. In fact some compounds are more potent and some are comparable with standard drugs. Keywords: Ferrocenyl & organic chalcone sulfides, Sulfones, Bis-sulfones, Thia-Michael addition reaction, m-CPBA, Bactericidal & fungicidal activitieshttp://www.sciencedirect.com/science/article/pii/S187853521400358X
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Naseem Ahmed Naveen Kumar Konduru Mohammad Owais
spellingShingle	Naseem Ahmed Naveen Kumar Konduru Mohammad Owais Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones Arabian Journal of Chemistry
author_facet	Naseem Ahmed Naveen Kumar Konduru Mohammad Owais
author_sort	Naseem Ahmed
title	Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
title_short	Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
title_full	Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
title_fullStr	Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
title_full_unstemmed	Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
title_sort	design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones
publisher	Elsevier
series	Arabian Journal of Chemistry
issn	1878-5352
publishDate	2019-12-01
description	A variety of different novel functionalized ferrocenyl chalcone and organic chalcone based sulfones and bis-sulfones were synthesized in excellent yield under mild reaction condition. The antimicrobial activities as bactericide and fungicide were evaluated for all the synthesized compounds and structure–activity relationships were established. Many compounds exhibited high and broad-range bactericidal activity. Among them, organic chalcone based on nitro-substituted 4c and chloro-substituted 6c, ferrocenyl chalcone based trimethoxy-substituted 20c and dimethyl-substituted 24c molecules displayed the best and broad-range bactericidal activity. Product 24c also exhibited the highest antifungal activity against most of the fungi tested. In fact some compounds are more potent and some are comparable with standard drugs. Keywords: Ferrocenyl & organic chalcone sulfides, Sulfones, Bis-sulfones, Thia-Michael addition reaction, m-CPBA, Bactericidal & fungicidal activities
url	http://www.sciencedirect.com/science/article/pii/S187853521400358X
work_keys_str_mv	AT naseemahmed designsynthesisandantimicrobialactivitiesofnovelferrocenylandorganicchalconebasedsulfonesandbissulfones AT naveenkumarkonduru designsynthesisandantimicrobialactivitiesofnovelferrocenylandorganicchalconebasedsulfonesandbissulfones AT mohammadowais designsynthesisandantimicrobialactivitiesofnovelferrocenylandorganicchalconebasedsulfonesandbissulfones
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Design, synthesis and antimicrobial activities of novel ferrocenyl and organic chalcone based sulfones and bis-sulfones

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