| Summary: | A variety of different novel functionalized ferrocenyl chalcone and organic chalcone based sulfones and bis-sulfones were synthesized in excellent yield under mild reaction condition. The antimicrobial activities as bactericide and fungicide were evaluated for all the synthesized compounds and structure–activity relationships were established. Many compounds exhibited high and broad-range bactericidal activity. Among them, organic chalcone based on nitro-substituted 4c and chloro-substituted 6c, ferrocenyl chalcone based trimethoxy-substituted 20c and dimethyl-substituted 24c molecules displayed the best and broad-range bactericidal activity. Product 24c also exhibited the highest antifungal activity against most of the fungi tested. In fact some compounds are more potent and some are comparable with standard drugs. Keywords: Ferrocenyl & organic chalcone sulfides, Sulfones, Bis-sulfones, Thia-Michael addition reaction, m-CPBA, Bactericidal & fungicidal activities
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