Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing

Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing

The subthalamic nucleus (STN) plays a key role in the pathophysiology of Parkinson's disease. This was demonstrated by the fact that STN neurons express more bursts in animal models of the disease and by the ability of STN inactivation to alleviate motor deficits. However, the origin of the bur...

Full description

Bibliographic Details
Main Authors: Claire Delaville, Jonathan Zapata, Laura Cardoit, Abdelhamid Benazzouz
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Subthalamic nucleus
Norepinephrine
Alpha 2 adrenergic receptors
Clonidine
Single unit microrecording
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002057

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112002057

Similar Items